Description：

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.

Chemical Information：

Molecular Weight (MW)		519.56
Formula		C23H20F3N5O2S2
CAS No.		1195765-45-7
Solubility (25°C) *	DMSO	30 mg/mL (57.74 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

FAK Pyk2 1.5 nM 14 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9247 mL	9.6235 mL	19.2471 mL
5 mM	0.3849 mL	1.9247 mL	3.8494 mL
10 mM	0.1925 mL	0.9624 mL	1.9247 mL
50 mM	0.0385 mL	0.1925 mL	0.3849 mL

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