Description：

Encorafenib (LGX818) is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM. Phase 3.

Chemical Information：

Molecular Weight (MW)		540.01
Formula		C22 H27 Cl F N7 O4 S
CAS No.		1269440-17-6
Solubility (25°C) *	DMSO	100 mg/mL (185.18 mM)
	Water	Insoluble
	Alcohol	100 mg/mL (185.18 mM)

Biological Activity：

Targets IC50

hCA II bCA IV hCA I 14 nM 36 nM 50 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.8518 mL	9.2591 mL	18.5182 mL
5 mM	0.3704 mL	1.8518 mL	3.7036 mL
10 mM	0.1852 mL	0.9259 mL	1.8518 mL
50 mM	0.0370 mL	0.1852 mL	0.3704 mL

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