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BMS-794833

BMS-794833

Catalog Number: CC2357 Rank: comment rank 5

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Description:

BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. Phase 1.

Chemical Information:

Molecular Weight (MW) 468.84
Formula

 

C23H15ClF2N4O3

 

CAS No. 1174046-72-0
Solubility (25°C) * DMSO 94 mg/mL (200.49 mM)
Water Insoluble
Alcohol Insoluble


Biological Activity:

Targets
IC50
procollagen C-pr
44 nM


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.1329 mL 10.6646 mL 21.3292 mL
5 mM 0.4266 mL 2.1329 mL 4.2658 mL
10 mM 0.2133 mL 1.0665 mL 2.1329 mL
50 mM 0.0427 mL 0.2133 mL 0.4266 mL


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