Description：

BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases. Phase 1/2.

Chemical Information：

Molecular Weight (MW)		512.89
Formula		C25H19ClF2N4O4
CAS No.		1025720-94-8
Solubility (25°C) *	DMSO	47 mg/mL (91.63 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

H+,K+-ATPase ~6.5 (pIC50) [1

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9497 mL	9.7487 mL	19.4974 mL
5 mM	0.3899 mL	1.9497 mL	3.8995 mL
10 mM	0.1950 mL	0.9749 mL	1.9497 mL
50 mM	0.0390 mL	0.1950 mL	0.3899 mL

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