Description：

AMG 458 is a potent c-Met inhibitor with K_i of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.

Chemical Information：

Molecular Weight (MW)		539.58
Formula		C30H29N5O5
CAS No.		913376-83-7
Solubility (25°C) *	DMSO	21 mg/mL (38.91 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

Microtubule (hum 0.1 pM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.8533 mL	9.2665 mL	18.5329 mL
5 mM	0.3707 mL	1.8533 mL	3.7066 mL
10 mM	0.1853 mL	0.9266 mL	1.8533 mL
50 mM	0.0371 mL	0.1853 mL	0.3707 mL

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