Description：

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

Chemical Information：

Molecular Weight (MW)		440.54
Formula		C27H28N4O2
CAS No.		1094614-85-3
Solubility (25°C) *	DMSO	60 mg/mL warmed (136.19 mM)
	Water	Insoluble
	Alcohol	80 mg/mL (181.59 mM)

Biological Activity：

Targets IC50

Pim1 Pim3 Pim2 FLT3 7 nM 69 nM 363 nM 44nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2699 mL	11.3497 mL	22.6994 mL
5 mM	0.4540 mL	2.2699 mL	4.5399 mL
10 mM	0.2270 mL	1.1350 mL	2.2699 mL
50 mM	0.0454 mL	0.2270 mL	0.4540 mL

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