Description：

Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Phase 3.

Chemical Information：

Molecular Weight (MW)		531.31
Formula		C21H21F3IN3O2
CAS No.		934660-93-2
Solubility (25°C) *	DMSO	100 mg/mL (188.21 mM)
	Water	Insoluble
	Alcohol	47 mg/mL warmed (88.46 mM)

Biological Activity：

Targets IC50

BRD3 BRD4 BRD2 0.25 μM 0.79 μM 0.5 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.8821 mL	9.4107 mL	18.8214 mL
5 mM	0.3764 mL	1.8821 mL	3.7643 mL
10 mM	0.1882 mL	0.9411 mL	1.8821 mL
50 mM	0.0376 mL	0.1882 mL	0.3764 mL

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