Description：

BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

Chemical Information：

Molecular Weight (MW)		412.48
Formula		C25H24N4O2
CAS No.		1094614-84-2
Solubility (25°C) *	DMSO	43 mg/mL (104.24 mM)
	Water	Insoluble
	Alcohol	3 mg/mL (7.27 mM)

Biological Activity：

Targets IC50

PARP1 PARP2 1 nM (EC50), 1 1.5 nM (Ki)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.4244 mL	12.1218 mL	24.2436 mL
5 mM	0.4849 mL	2.4244 mL	4.8487 mL
10 mM	0.2424 mL	1.2122 mL	2.4244 mL
50 mM	0.0485 mL	0.2424 mL	0.4849 mL

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