Description：

AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM).

Chemical Information：

Molecular Weight (MW)		469.54
Formula		C22H31N9O3
CAS No.		1620576-64-8
Solubility (25°C) *	DMSO	93 mg/mL (198.06 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

Flt3ITD Flt3wt 1.1 nM 4.2 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1297 mL	10.6487 mL	21.2974 mL
5 mM	0.4259 mL	2.1297 mL	4.2595 mL
10 mM	0.2130 mL	1.0649 mL	2.1297 mL
50 mM	0.0426 mL	0.2130 mL	0.4259 mL

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