Description：

BGT226 (NVP-BGT226) is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.

Chemical Information：

Molecular Weight (MW)		650.6
Formula		C28H25F3N6O2.C4H4O
CAS No.		1245537-68-1
Solubility (25°C) *	DMSO	30 mg/mL (46.11 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

EGFR ErbB2 10.8 nM 9.2 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.5370 mL	7.6852 mL	15.3704 mL
5 mM	0.3074 mL	1.5370 mL	3.0741 mL
10 mM	0.1537 mL	0.7685 mL	1.5370 mL
50 mM	0.0307 mL	0.1537 mL	0.3074 mL

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