Description：

AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with K_i of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.

Chemical Information：

Molecular Weight (MW)		334.37
Formula		C19H18N4O2
CAS No.		612487-72-6
Solubility (25°C) *	DMSO	52 mg/mL (155.51 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

TGF-β1 (ALK5) 14.3 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.9907 mL	14.9535 mL	29.9070 mL
5 mM	0.5981 mL	2.9907 mL	5.9814 mL
10 mM	0.2991 mL	1.4953 mL	2.9907 mL
50 mM	0.0598 mL	0.2991 mL	0.5981 mL

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