Description：

Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.

Chemical Information：

Molecular Weight (MW)		386.47
Formula		C22H18N4OS
CAS No.		319460-85-0
Solubility (25°C) *	DMSO	35 mg/mL warmed (90.56 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

FTase 0.6 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.5875 mL	12.9376 mL	25.8752 mL
5 mM	0.5175 mL	2.5875 mL	5.1750 mL
10 mM	0.2588 mL	1.2938 mL	2.5875 mL
50 mM	0.0518 mL	0.2588 mL	0.5175 mL

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