Description：

Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit, ~10-fold more selective for VEGFR than PDGFR and Ret. Phase 3.

Chemical Information：

Molecular Weight (MW)		569.44
Formula		C22H23N5O.2H3PO4
CAS No.		857876-30-3
Solubility (25°C) *	DMSO	100 mg/mL warmed (175.61 mM)
	Water	19 mg/mL warmed (33.36 mM)
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.7561 mL	8.7806 mL	17.5611 mL
5 mM	0.3512 mL	1.7561 mL	3.5122 mL
10 mM	0.1756 mL	0.8781 mL	1.7561 mL
50 mM	0.0351 mL	0.1756 mL	0.3512 mL

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