Description：

MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. Phase 1/2. .

Chemical Information：

Molecular Weight (MW)		495.55
Formula		C24H25N5O5S
CAS No.		917879-39-1
Solubility (25°C) *	DMSO	99 mg/mL (199.77 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0180 mL	10.0898 mL	20.1796 mL
5 mM	0.4036 mL	2.0180 mL	4.0359 mL
10 mM	0.2018 mL	1.0090 mL	2.0180 mL
50 mM	0.0404 mL	0.2018 mL	0.4036 mL

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