Description：

Apabetalone (RVX-208) is a potent BET bromodomain inhibitor with IC50 of 0.510 μM for BD2 in a cell-free assay, about 170-fold selectivity over BD1. Phase 2.

Chemical Information：

Molecular Weight (MW)		370.4
Formula		C20H22N2O5
CAS No.		1044870-39-4
Solubility (25°C) *	DMSO	74 mg/mL (199.78 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

DNA (JURKAT cell DNA (PER-255 ce DNA (ALL-SIL ce DNA (HSB2 cell 2.15 μM 0.067 μM 1.24 μM 0.44 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.6998 mL	13.4989 mL	26.9978 mL
5 mM	0.5400 mL	2.6998 mL	5.3996 mL
10 mM	0.2700 mL	1.3499 mL	2.6998 mL
50 mM	0.0540 mL	0.2700 mL	0.5400 mL

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