Description：

A-1210477 is a potent and selective MCL-1 inhibitor with K_i and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members.

Chemical Information：

Molecular Weight (MW)		850.04
Formula		C46H55N7O7S
CAS No.		1668553-26-1
Solubility (25°C) *	DMSO	3 mg/mL warmed (3.52 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

EGFRL858R HER2 EGFR L858R/T790 EGFRwt 0.4 nM 14 nM 10 nM 0.5 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.1764 mL	5.8821 mL	11.7642 mL
5 mM	0.2353 mL	1.1764 mL	2.3528 mL
10 mM	0.1176 mL	0.5882 mL	1.1764 mL
50 mM	0.0235 mL	0.1176 mL	0.2353 mL

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