Description：

A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).

Chemical Information：

Molecular Weight (MW)		669.79
Formula		C35H32FN5O4S2
CAS No.		1235034-55-5
Solubility (25°C) *	DMSO	80 mg/mL (119.44 mM)
	Water	Insoluble
	Alcohol	100 mg/mL (149.3 mM)

Biological Activity：

Targets IC50

FGFR1/2/3 PDGFRα/β VEGFR1/2/3 69 nM/37 nM/108 59 nM/65 nM 34 nM/13 nM/13

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.4930 mL	7.4650 mL	14.9301 mL
5 mM	0.2986 mL	1.4930 mL	2.9860 mL
10 mM	0.1493 mL	0.7465 mL	1.4930 mL
50 mM	0.0299 mL	0.1493 mL	0.2986 mL

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