Description：

Entospletinib (GS-9973) is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM in a cell-free assay and showed 13- to >1000-fold cellular selectivity for Syk over other kinases(including Jak2, ckit, Flt3, Ret, KDR) as assessed by target protein phosphorylation or functional response.

Chemical Information：

Molecular Weight (MW)		411.46
Formula		C23H21N7O
CAS No.		1229208-44-9
Solubility (25°C) *	DMSO	26 mg/mL warmed (63.18 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

COX-2

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.4304 mL	12.1518 mL	24.3037 mL
5 mM	0.4861 mL	2.4304 mL	4.8607 mL
10 mM	0.2430 mL	1.2152 mL	2.4304 mL
50 mM	0.0486 mL	0.2430 mL	0.4861 mL

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