Description：

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.

Chemical Information：

Molecular Weight (MW)		549.02
Formula		C29H32ClF3N2O3
CAS No.		913358-93-7
Solubility (25°C) *	DMSO	72 mg/mL (131.14 mM)
	Water	Insoluble
	Alcohol	51 mg/mL (92.89 mM)

Biological Activity：

Targets IC50

CDK6/cyclin D2 CDK4/cyclin D1 16 nM 11 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.8214 mL	9.1071 mL	18.2143 mL
5 mM	0.3643 mL	1.8214 mL	3.6429 mL
10 mM	0.1821 mL	0.9107 mL	1.8214 mL
50 mM	0.0364 mL	0.1821 mL	0.3643 mL

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