Description：

Eltanexor(KPT-8602) is a second-generation, orally bioavailable XPO1 inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure.

Chemical Information：

Molecular Weight (MW)		428.29
Formula		C17H10F6N6O
CAS No.		1642300-52-4
Solubility (25°C) *	DMSO	85 mg/mL warmed (198.46 mM)
	Water	Insoluble
	Alcohol	1 mg/mL warmed (2.33 mM)

Biological Activity：

Targets IC50

WKY-E SHR-E 162.5 nM 170.3 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3349 mL	11.6743 mL	23.3487 mL
5 mM	0.4670 mL	2.3349 mL	4.6697 mL
10 mM	0.2335 mL	1.1674 mL	2.3349 mL
50 mM	0.0467 mL	0.2335 mL	0.4670 mL

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