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Description:
EED226 is a potent, selective, and orally bioavailable a novel allosteric Polycomb repressive complex 2 (PRC2) inhibitor with an IC50 of 23.4 nM when the H3K27me0 peptide was used as substrate and an IC50 of 53.5 nM when the mononucleosome was used as the substrate. It directly binds to the H3K27me3 binding pocket of EED.
Chemical Information:
Molecular Weight (MW) 369.40 Formula
C17H15N5O3S
CAS No. 2083627-02-3 Solubility (25°C) * DMSO 73 mg/mL warmed (197.61 mM) Water Insoluble Alcohol Insoluble
Biological Activity:
Targets IC50
cyclooxygenase
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg 1 mM 2.7071 mL 13.5355 mL 27.0709 mL 5 mM 0.5414 mL 2.7071 mL 5.4142 mL 10 mM 0.2707 mL 1.3535 mL 2.7071 mL 50 mM 0.0541 mL 0.2707 mL 0.5414 mL
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