Description：

Droxinostat is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.

Chemical Information：

Molecular Weight (MW)		243.69
Formula		C11H14ClNO3
CAS No.		99873-43-5
Solubility (25°C) *	DMSO	49 mg/mL (201.07 mM)
	Water	Insoluble
	Alcohol	49 mg/mL (201.07 mM)

Biological Activity：

Targets IC50

α1 Adrenergic 5-HT Norepinephrine H1 10 μM 1.07 μM 8.2 nM 1.4 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	4.1036 mL	20.5179 mL	41.0357 mL
5 mM	0.8207 mL	4.1036 mL	8.2071 mL
10 mM	0.4104 mL	2.0518 mL	4.1036 mL
50 mM	0.0821 mL	0.4104 mL	0.8207 mL

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