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Doxorubicin (Adriamycin) HCl

Doxorubicin (Adriamycin) HCl

Catalog Number: CC1364 Rank: comment rank 5

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Description:

Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.

Chemical Information:

Molecular Weight (MW) 579.98
Formula

 

C27H29NO11.HCl

 

CAS No. 25316-40-9
Solubility (25°C) * DMSO 100 mg/mL warmed (172.41 mM)
Water 20 mg/mL (34.48 mM)
Alcohol Insoluble


Biological Activity:

Targets
IC50
Sigma 1 receptor 5-HT2 Norepinephrine Serotonin recep 5-HT4
287 nM 235 nM 13.3 nM 3.45 nM 7.31 nM


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.7242 mL 8.6210 mL 17.2420 mL
5 mM 0.3448 mL 1.7242 mL 3.4484 mL
10 mM 0.1724 mL 0.8621 mL 1.7242 mL
50 mM 0.0345 mL 0.1724 mL 0.3448 mL


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