Description：

Dovitinib (TKI258) Lactate is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.

Chemical Information：

Molecular Weight (MW)		482.51
Formula		C24H27FN6O4
CAS No.		915769-50-5
Solubility (25°C) *	DMSO	100 mg/mL (207.24 mM)
	Water	66 mg/mL warmed (136.78 mM)
	Alcohol	1 mg/mL warmed (2.07 mM)

Biological Activity：

Targets IC50

norepinephrine ( 5 nM (Ki)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0725 mL	10.3625 mL	20.7250 mL
5 mM	0.4145 mL	2.0725 mL	4.1450 mL
10 mM	0.2072 mL	1.0362 mL	2.0725 mL
50 mM	0.0414 mL	0.2072 mL	0.4145 mL

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