Description：

Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3.

Chemical Information：

Molecular Weight (MW)		518.92
Formula		C27H20ClFN4O4
CAS No.		1028486-01-2
Solubility (25°C) *	DMSO	27 mg/mL (52.03 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

Plk1 0.83 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9271 mL	9.6354 mL	19.2708 mL
5 mM	0.3854 mL	1.9271 mL	3.8542 mL
10 mM	0.1927 mL	0.9635 mL	1.9271 mL
50 mM	0.0385 mL	0.1927 mL	0.3854 mL

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