Description：

Dolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM in a cell-free assay, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.

Chemical Information：

Molecular Weight (MW)		419.38
Formula		C20H19F2N3O5
CAS No.		1051375-16-6
Solubility (25°C) *	DMSO	83 mg/mL warmed (197.91 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3845 mL	11.9224 mL	23.8447 mL
5 mM	0.4769 mL	2.3845 mL	4.7689 mL
10 mM	0.2384 mL	1.1922 mL	2.3845 mL
50 mM	0.0477 mL	0.2384 mL	0.4769 mL

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