Description：

Alectinib (CH5424802) is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429.

Chemical Information：

Molecular Weight (MW)		482.62
Formula		C30H34N4O2
CAS No.		1256580-46-7
Solubility (25°C) *	DMSO	0.5 mg/mL warmed (1.03 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

B-Raf 0.13 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0720 mL	10.3601 mL	20.7202 mL
5 mM	0.4144 mL	2.0720 mL	4.1440 mL
10 mM	0.2072 mL	1.0360 mL	2.0720 mL
50 mM	0.0414 mL	0.2072 mL	0.4144 mL

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