Description：

Decernotinib (VX-509) is a potent and selective JAK3 inhibitor with K_i of 2.5 nM, >4-fold selectivity over JAK1, JAK2, and TYK2, respectively. Phase 2/3.

Chemical Information：

Molecular Weight (MW)		392.38
Formula		C18H19F3N6O
CAS No.		944842-54-0
Solubility (25°C) *	DMSO	78 mg/mL (198.78 mM)
	Water	Insoluble
	Alcohol	20 mg/mL warmed (50.97 mM)

Biological Activity：

Targets IC50

p38α 7.1 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.5485 mL	12.7427 mL	25.4855 mL
5 mM	0.5097 mL	2.5485 mL	5.0971 mL
10 mM	0.2549 mL	1.2743 mL	2.5485 mL
50 mM	0.0510 mL	0.2549 mL	0.5097 mL

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