Description：

Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2.

Chemical Information：

Molecular Weight (MW)		474.55
Formula		C26H30N6O3
CAS No.		827318-97-8
Solubility (25°C) *	DMSO	95 mg/mL (200.18 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

VEGFR2 ChK2 Fms Yes ChK1 8 nM (Ki) 47 nM (Ki) 10 nM (Ki) 14 nM (Ki) 0.49 nM (Ki)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1073 mL	10.5363 mL	21.0726 mL
5 mM	0.4215 mL	2.1073 mL	4.2145 mL
10 mM	0.2107 mL	1.0536 mL	2.1073 mL
50 mM	0.0421 mL	0.2107 mL	0.4215 mL

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