Description：

Danoprevir(ITMN-191) is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM, inhibition effect for HCV genotypes 1A/1B/4/5/6 is ~10-fold higher than 2B/3A. Phase 2.

Chemical Information：

Molecular Weight (MW)		731.83
Formula		C35H46FN5O9S
CAS No.		850876-88-9
Solubility (25°C) *	DMSO	144 mg/mL (196.76 mM)
	Water	Insoluble
	Alcohol	144 mg/mL (196.76 mM)

Biological Activity：

Targets IC50

CYP3A 30 - 285 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.3664 mL	6.8322 mL	13.6644 mL
5 mM	0.2733 mL	1.3664 mL	2.7329 mL
10 mM	0.1366 mL	0.6832 mL	1.3664 mL
50 mM	0.0273 mL	0.1366 mL	0.2733 mL

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