Description：

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3^TopBP1-ER cell.

Chemical Information：

Molecular Weight (MW)		469.55
Formula		C30H23N5O
CAS No.		915019-65-7
Solubility (25°C) *	DMSO	0.01 mg/mL (0.02 mM)
	Water	Insoluble
	Alcohol

Biological Activity：

Targets IC50

EGFR PDGFR 460 μM 0.5 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1297 mL	10.6485 mL	21.2970 mL
5 mM	0.4259 mL	2.1297 mL	4.2594 mL
10 mM	0.2130 mL	1.0648 mL	2.1297 mL
50 mM	0.0426 mL	0.2130 mL	0.4259 mL

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