Description：

D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM.

Chemical Information：

Molecular Weight (MW)		398.41
Formula		C23H18N4O3
CAS No.		301836-43-1
Solubility (25°C) *	DMSO	79 mg/mL (198.28 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

c-Raf 9 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.5100 mL	12.5499 mL	25.0998 mL
5 mM	0.5020 mL	2.5100 mL	5.0200 mL
10 mM	0.2510 mL	1.2550 mL	2.5100 mL
50 mM	0.0502 mL	0.2510 mL	0.5020 mL

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