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Cyclosporine

Cyclosporine

Catalog Number: CC1670 Rank: comment rank 5

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Description:

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

Chemical Information:

Molecular Weight (MW) 1202.61
Formula

 

C62H111N11O12

 

CAS No. 79217-60-0
Solubility (25°C) * DMSO 100 mg/mL warmed (83.15 mM)
Water Insoluble
Alcohol 100 mg/mL (83.15 mM)


Biological Activity:

Targets
IC50
5-HT1E 5-HT1A 5-HT1D 5-HT1B 5-HT1F
8.7 (pKi) 7.2 (pKi) 7.2 (pKi) 6.9 (pKi) 9.25 (pKi)


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 0.8315 mL 4.1576 mL 8.3152 mL
5 mM 0.1663 mL 0.8315 mL 1.6630 mL
10 mM 0.0832 mL 0.4158 mL 0.8315 mL
50 mM 0.0166 mL 0.0832 mL 0.1663 mL


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