Description：

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

Chemical Information：

Molecular Weight (MW)		1202.61
Formula		C62H111N11O12
CAS No.		59865-13-3
Solubility (25°C) *	DMSO	100 mg/mL warmed (83.15 mM)
	Water	Insoluble
	Alcohol	100 mg/mL warmed (83.15 mM)

Biological Activity：

Targets IC50

JAK1 JAK2 5.9 nM 5.7 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	0.8315 mL	4.1576 mL	8.3152 mL
5 mM	0.1663 mL	0.8315 mL	1.6630 mL
10 mM	0.0832 mL	0.4158 mL	0.8315 mL
50 mM	0.0166 mL	0.0832 mL	0.1663 mL

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