Description：

CYC116 is a potent inhibitor of Aurora A/B with K_i of 8.0 nM/9.2 nM, is less potent to VEGFR2 (K_i of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.

Chemical Information：

Molecular Weight (MW)		368.46
Formula		C18H20N6OS
CAS No.		693228-63-6
Solubility (25°C) *	DMSO	24 mg/mL warmed (65.13 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

FAAH (human) FAAH (rat) 12 nM 10 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.7140 mL	13.5700 mL	27.1400 mL
5 mM	0.5428 mL	2.7140 mL	5.4280 mL
10 mM	0.2714 mL	1.3570 mL	2.7140 mL
50 mM	0.0543 mL	0.2714 mL	0.5428 mL

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