Description：

CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.

Chemical Information：

Molecular Weight (MW)		513.61
Formula		C27H27N7O2S
CAS No.		1138549-36-6
Solubility (25°C) *	DMSO	0.02 mg/mL (0.03 mM)
	Water	Insoluble
	Alcohol

Biological Activity：

Targets IC50

EGFR 2 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9470 mL	9.7350 mL	19.4700 mL
5 mM	0.3894 mL	1.9470 mL	3.8940 mL
10 mM	0.1947 mL	0.9735 mL	1.9470 mL
50 mM	0.0389 mL	0.1947 mL	0.3894 mL

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