Description：

Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRα/β with K_d of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src.

Chemical Information：

Molecular Weight (MW)		443.54
Formula		C26H29N5O2
CAS No.		670220-88-9
Solubility (25°C) *	DMSO	88 mg/mL warmed (198.4 mM)
	Water	Insoluble
	Alcohol	7 mg/mL (15.78 mM)

Biological Activity：

Targets IC50

Bcl-xL Mcl-1 Bcl-2 0.48 μM (Ki) 0.18 μM (Ki) [1 0.32 μM (Ki)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2546 mL	11.2729 mL	22.5459 mL
5 mM	0.4509 mL	2.2546 mL	4.5092 mL
10 mM	0.2255 mL	1.1273 mL	2.2546 mL
50 mM	0.0451 mL	0.2255 mL	0.4509 mL

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