Description：

Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with K_i of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.

Chemical Information：

Molecular Weight (MW)		427.32
Formula		C18H17Cl2FN4OS
CAS No.		1047644-62-1
Solubility (25°C) *	DMSO	85 mg/mL (198.91 mM)
	Water	Insoluble
	Alcohol	85 mg/mL (198.91 mM)

Biological Activity：

Targets IC50

FGFR VEGFR2 148 nM 25 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3402 mL	11.7008 mL	23.4017 mL
5 mM	0.4680 mL	2.3402 mL	4.6803 mL
10 mM	0.2340 mL	1.1701 mL	2.3402 mL
50 mM	0.0468 mL	0.2340 mL	0.4680 mL

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