Description：

CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.

Chemical Information：

Molecular Weight (MW)		545.53
Formula		C26H27F4N7O2
CAS No.		1375465-09-0
Solubility (25°C) *	DMSO	100 mg/mL (183.3 mM)
	Water	Insoluble
	Alcohol	29 mg/mL (53.15 mM)

Biological Activity：

Targets IC50

Smoothened (Smo) Smoothened (Smo 4.6 nM (Ki) 5.8 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.8331 mL	9.1654 mL	18.3308 mL
5 mM	0.3666 mL	1.8331 mL	3.6662 mL
10 mM	0.1833 mL	0.9165 mL	1.8331 mL
50 mM	0.0367 mL	0.1833 mL	0.3666 mL

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