Description：

Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.

Chemical Information：

Molecular Weight (MW)		717.18
Formula		C24H25ClFN5O3.2C4H4O4
CAS No.		850140-73-7
Solubility (25°C) *	DMSO	100 mg/mL (139.43 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

Hedgehog 3 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.3944 mL	6.9718 mL	13.9435 mL
5 mM	0.2789 mL	1.3944 mL	2.7887 mL
10 mM	0.1394 mL	0.6972 mL	1.3944 mL
50 mM	0.0279 mL	0.1394 mL	0.2789 mL

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