Description：

AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.

Chemical Information：

Molecular Weight (MW)		440.58
Formula		C27H32N6
CAS No.		497839-62-0
Solubility (25°C) *	DMSO	88 mg/mL (199.73 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

EGFR EGFR 5.2 pM (Ki) 29 pM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2697 mL	11.3487 mL	22.6974 mL
5 mM	0.4539 mL	2.2697 mL	4.5395 mL
10 mM	0.2270 mL	1.1349 mL	2.2697 mL
50 mM	0.0454 mL	0.2270 mL	0.4539 mL

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