Description：

Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively.

Chemical Information：

Molecular Weight (MW)		424.8
Formula		C14H19ClN4O2.C2HF3O2
CAS No.		1043444-18-3
Solubility (25°C) *	DMSO	84 mg/mL warmed (197.74 mM)
	Water	70 mg/mL warmed (164.78 mM)
	Alcohol	84 mg/mL warmed (197.74 mM)

Biological Activity：

Targets IC50

PI3Kδ PI3Kγ PI3Kβ mTOR PI3Kα 14 nM 16 nM 7 nM 3 nM 2 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3540 mL	11.7702 mL	23.5405 mL
5 mM	0.4708 mL	2.3540 mL	4.7081 mL
10 mM	0.2354 mL	1.1770 mL	2.3540 mL
50 mM	0.0471 mL	0.2354 mL	0.4708 mL

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