Description：

ADX47273 is a potent and specific mGlu5 positive allosteric modulator(PAM) with EC50 of 0.17 μM, showing no activity at other mGlu subtypes.

Chemical Information：

Molecular Weight (MW)		369.36
Formula		C20H17F2N3O2
CAS No.		851881-60-2
Solubility (25°C) *	DMSO	74 mg/mL (200.34 mM)
	Water	Insoluble
	Alcohol	30 mg/mL (81.22 mM)

Biological Activity：

Targets IC50

p38α p38β 50 nM 100 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.7074 mL	13.5369 mL	27.0739 mL
5 mM	0.5415 mL	2.7074 mL	5.4148 mL
10 mM	0.2707 mL	1.3537 mL	2.7074 mL
50 mM	0.0541 mL	0.2707 mL	0.5415 mL

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