Description：

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs.

Chemical Information：

Molecular Weight (MW)		465.34
Formula		C22H18Cl2N8
CAS No.		252917-06-9
Solubility (25°C) *	DMSO	10 mg/mL warmed (21.48 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

CBP 3 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1490 mL	10.7448 mL	21.4897 mL
5 mM	0.4298 mL	2.1490 mL	4.2979 mL
10 mM	0.2149 mL	1.0745 mL	2.1490 mL
50 mM	0.0430 mL	0.2149 mL	0.4298 mL

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