Description：

CC-292 (AVL-292) is a covalent, orally active, and highly selective BTK inhibitor with IC50 of <0.5 nM, displaying at least 1400-fold selectivity over the other kinases assayed. Phase 1.

Chemical Information：

Molecular Weight (MW)		423.44
Formula		C22H22FN5O3
CAS No.		1202757-89-8
Solubility (25°C) *	DMSO	85 mg/mL (200.73 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

DNA topoisomeras

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3616 mL	11.8080 mL	23.6161 mL
5 mM	0.4723 mL	2.3616 mL	4.7232 mL
10 mM	0.2362 mL	1.1808 mL	2.3616 mL
50 mM	0.0472 mL	0.2362 mL	0.4723 mL

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