Description：

AD80, a multikinase inhibitor, shows strong activity against human RET, BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.

Chemical Information：

Molecular Weight (MW)		473.43
Formula		C22H19F4N7O
CAS No.		1384071-99-1
Solubility (25°C) *	DMSO	94 mg/mL (198.55 mM)
	Water	Insoluble
	Alcohol	94 mg/mL (198.55 mM)

Biological Activity：

Targets IC50

Mdm2 90 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1122 mL	10.5612 mL	21.1224 mL
5 mM	0.4224 mL	2.1122 mL	4.2245 mL
10 mM	0.2112 mL	1.0561 mL	2.1122 mL
50 mM	0.0422 mL	0.2112 mL	0.4224 mL

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