Description：

Cabozantinib malate (XL184) is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively.

Chemical Information：

Molecular Weight (MW)		635.59
Formula		C28H24FN3O5.C4H6O5
CAS No.		1140909-48-3
Solubility (25°C) *	DMSO	100 mg/mL (157.33 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.5733 mL	7.8667 mL	15.7334 mL
5 mM	0.3147 mL	1.5733 mL	3.1467 mL
10 mM	0.1573 mL	0.7867 mL	1.5733 mL
50 mM	0.0315 mL	0.1573 mL	0.3147 mL

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