Description：

Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with K_i of 4.7 nM and 95 nM, respectively.

Chemical Information：

Molecular Weight (MW)		569.63
Formula		C27H29N5O6S.H2O
CAS No.		157212-55-0
Solubility (25°C) *	DMSO	100 mg/mL (175.55 mM)
	Water	0.001 mg/mL (0.0 mM)
	Alcohol	2 mg/mL (3.51 mM)

Biological Activity：

Targets IC50

c-Kit PDGFRα VEGFR2/3 1 nM 15 nM 6 nM/4 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.7555 mL	8.7776 mL	17.5553 mL
5 mM	0.3511 mL	1.7555 mL	3.5111 mL
10 mM	0.1756 mL	0.8778 mL	1.7555 mL
50 mM	0.0351 mL	0.1756 mL	0.3511 mL

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