Description：

Bisindolylmaleimide I (GF109203X) is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.

Chemical Information：

Molecular Weight (MW)		412.48
Formula		C25H24N4O2
CAS No.		133052-90-1
Solubility (25°C) *	DMSO	82 mg/mL (198.79 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

EGFR ErbB2 ErbB4 EGFRT790M/L858R 0.5 nM 3.0 nM 0.8 nM 12 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.4244 mL	12.1218 mL	24.2436 mL
5 mM	0.4849 mL	2.4244 mL	4.8487 mL
10 mM	0.2424 mL	1.2122 mL	2.4244 mL
50 mM	0.0485 mL	0.2424 mL	0.4849 mL

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