Description：

Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis.

Chemical Information：

Molecular Weight (MW)		494.32
Formula		C22H12BrN3O4S
CAS No.		1420071-30-2
Solubility (25°C) *	DMSO	43 mg/mL warmed (86.98 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

20S proteasome 3.4 nM (IC50）,

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0230 mL	10.1149 mL	20.2298 mL
5 mM	0.4046 mL	2.0230 mL	4.0460 mL
10 mM	0.2023 mL	1.0115 mL	2.0230 mL
50 mM	0.0405 mL	0.2023 mL	0.4046 mL

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